Flexible non-invasive sensor for neurotransmitter monitoring inspired by AgBiS2/PEDOT:PSS

The neurotransmitter dopamine plays an essential role in determining human psychological behavior, and its abnormality can lead to severe psychological diseases. Therefore, rapid assessment and initial diagnosis are crucial. In this study, a AgBiS2/PEDOT:PSS in the composite material contributes to its improved performance as an electrochemical sensor. The developed AgBiS2/PEDOT:PSS/GCE electrode exhibited a lower impedance (28 Ω) compared to other modified electrodes. It demonstrated a low limit of detection (0.0026 µM), high sensitivity (1.4872 µA µM−1 cm−2), a wide linear range (0.0875–937.5 µM) and good reproducibility and repeatability. Furthermore, the sensor showed exceptional selectivity even in the presence of potential interfering substances such as glucose, ascorbic acid, and uric acid. Satisfactory recovery results were obtained for the detection of dopamine in human fluids, including blood, urine, and saliva.