孟德尔随机化
医学
唾液腺
内科学
随机化
肿瘤科
皮肤病科
病理
临床试验
基因型
遗传学
遗传变异
生物
基因
作者
Yan Gao,Huihong Chen,Yong Liu,Xin Zhang,Yuanzheng Qiu,Donghai Huang
出处
期刊:Oral Diseases
[Wiley]
日期:2023-07-27
卷期号:30 (4): 2245-2253
被引量:3
摘要
Abstract Background Observational studies have found associations between smoking, alcohol, radiation, body mass index (BMI), periodontitis, and the hazard of benign salivary gland neoplasms (BSGNs). Nevertheless, the etiology of BSGNs remains unclear. This study aims to assess the causal association between these modifiable factors and the BSGNs. Methods Genetic instruments associated with exposures at the genome‐wide significance level were selected from corresponding genome‐wide association studies. The summary statistics for BSGNs were obtained from the FinnGen consortium (2445 cases and 340,054 controls). The inverse variance‐weighted method was used as the primary analysis, and several sensitivity analyses were performed to test the reliability. Results Genetically predicted higher lifetime smoking index (odds ratio [OR] = 2.10, p = 0.012) and BMI (OR = 1.58, p = 2.29 × 10 −5 ) were associated with elevated risk of BSGNs, whereas other exposures do not. Sensitivity analyses showed consistency. The causal effect of the lifetime smoking index became more significant after adjusting for BMI (OR = 2.89, p = 0.005) and alcohol consumption (OR = 2.49, p = 0.002). A slight negative association emerged for alcohol consumption with adjustment for cigarettes per day (OR = 0.53, p = 0.034) but disappeared when adjusting for cigarettes per day and BMI. Conclusion This study supports the independent causal role of lifetime smoking index and BMI in BSGNs risk.
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