油酸烷
脐静脉
细胞粘附分子
三萜类
分子
立体化学
圆二色性
化学
粘附
VCAM-1
细胞粘附
生物
生物化学
三萜
免疫学
医学
病理
体外
有机化学
替代医学
作者
Rujia Jiang,Lingwen Yao,Yingjun Lv,Z. H. Guo,Feifei Wang,Hong-Hua Cui,Yuanyuan Cheng,Feng Wang
标识
DOI:10.1016/j.phytochem.2023.113905
摘要
Three unusual oleanane-derived triterpenoids, stytontriterpenes A-C (1-3), were isolated from the resin of Styrax tonkinensis together with an oleanane-lactone (stytontriterpene D, 4). Their structures and absolute configurations were characterised using a combination of spectroscopic analysis, electronic circular dichroism, and theoretical calculations. 1 and 2 belong to nor-oleanane with rare spiro D/E rings and 3 contains one infrequent C32 scaffold. 1 considerably suppressed the number of adhered leukemic monocytes (THP-1) to human umbilical vein endothelial cells and attenuated the upregulations of mRNA and protein levels of intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 at 5 μM, suggesting that 1 might be a promising anti-vascular inflammatory chemical for atherosclerosis therapy. Plausible biosynthetic pathways for 1-4 are also proposed.
科研通智能强力驱动
Strongly Powered by AbleSci AI