神经发生
室下区
亚颗粒带
神经干细胞
神经科学
齿状回
嗅球
生物
神经上皮细胞
干细胞
胚胎干细胞
成体干细胞
侧脑室
神经发育
海马体
细胞生物学
中枢神经系统
遗传学
基因
作者
Ghulam Hussain,Rabia Akram,Haseeb Anwar,Faiqa Sajid,Tehreem Iman,Hyung Soo Han,Chand Raza,José Juan Zúñiga-Aguilar
标识
DOI:10.4103/1673-5374.375317
摘要
Adult neurogenesis, the process of creating new neurons, involves the coordinated division, migration, and differentiation of neural stem cells. This process is restricted to neurogenic niches located in two distinct areas of the brain: the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle, where new neurons are generated and then migrate to the olfactory bulb. Neurogenesis has been thought to occur only during the embryonic and early postnatal stages and to decline with age due to a continuous depletion of neural stem cells. Interestingly, recent years have seen tremendous progress in our understanding of adult brain neurogenesis, bridging the knowledge gap between embryonic and adult neurogenesis. Here, we discuss the current status of adult brain neurogenesis in light of what we know about neural stem cells. In this notion, we talk about the importance of intracellular signaling molecules in mobilizing endogenous neural stem cell proliferation. Based on the current understanding, we can declare that these molecules play a role in targeting neurogenesis in the mature brain. However, to achieve this goal, we need to avoid the undesired proliferation of neural stem cells by controlling the necessary checkpoints, which can lead to tumorigenesis and prove to be a curse instead of a blessing or hope.
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