勃起功能障碍
内皮功能障碍
内科学
脐静脉
内皮
内分泌学
细胞凋亡
平均动脉压
医学
勃起功能
血压
化学
男科
生物
遗传学
心率
体外
作者
Xuan Zhou,Lebin Song,Rong Cong,Jiaochen Luan,Xiang Zhou,Yichun Wang,Liangyu Yao,Xu Zhang,Xiaohan Ren,Tongtong Zhang,Mengchi Yu,Na Song
出处
期刊:Chemosphere
[Elsevier]
日期:2022-12-01
卷期号:308: 136486-136486
被引量:3
标识
DOI:10.1016/j.chemosphere.2022.136486
摘要
Decabromodiphenyl ether (mainly BDE-209) is a commonly used brominated flame retardant in various industrial products. Although its damage to the reproduction system has been established, its effect on erectile function remains unclear. The present study investigated whether BDE-209 induced erectile dysfunction in male SD rats and the underlying mechanisms. Pubertal male rats were exposed to BDE-209 orally (0, 5, 50, and 500 mg/kg/day) for 28 days and the ICP (intracavernous pressure) and MAP (mean arterial pressure) were measured. After the rats were euthanized, the fibrosis and apoptosis levels were evaluated. Additionally, the endothelial function of the rat vascular endothelium cells and the human umbilical vein endothelial cells were impaired after treatment with 50 μM and 100 μM BDE-209. Moreover, the bioinformatics based on CTD database and ChIP-X Enrichment Analysis, version 3 (ChEA3) and molecular docking analysis demonstrated that 5 transcription factors (NFKB1, NR3C1, E2F5, REL, IRF4) might regulate endothelial function by affecting the expression of interactive genes (BCL-2, CAP3, CAT, TNF, MAPK1, and MAPK3). In summary, the present study demonstrated that BDE-209 might affect downstream interactive genes by binding to transcription factors, leading to corpus cavernosum endothelial dysfunction, thus contributing to erectile dysfunction in rats.
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