精神分裂症(面向对象编程)
双相情感障碍
精神科
医学
粒线体疾病
诱导多能干细胞
重性抑郁障碍
情绪障碍
心理学
线粒体DNA
认知
生物
焦虑
遗传学
胚胎干细胞
基因
作者
Peiyan Ni,Yao Ma,Sangmi Chung
标识
DOI:10.1016/j.schres.2022.08.027
摘要
Psychiatric disorders are a heterogeneous group of mental disorders with abnormal mental or behavioral patterns, which severely distress or disable affected individuals and can have a grave socioeconomic burden. Growing evidence indicates that mitochondrial function plays an important role in developing psychiatric disorders. This review discusses the neuropsychiatric consequences of mitochondrial abnormalities in both animal models and patients. We also discuss recent studies associated with compromised mitochondrial function in various psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MD), and bipolar disorders (BD). These studies employ various approaches including postmortem studies, imaging studies, genetic studies, and induced pluripotent stem cells (iPSCs) studies. We also summarize the evidence from animal models and clinical trials to support mitochondrial function as a potential therapeutic target to treat various psychiatric disorders. This review will contribute to furthering our understanding of the metabolic etiology of various psychiatric disorders, and help guide the development of optimal therapies.
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