Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs
化学
生物利用度
药理学
医学
作者
Marisa Actis,Joel O. Cresser-Brown,Elizabeth A. Caine,Martin Steger,Anup Aggarwal,Anand Mayasundari,Nancy E. Murphy,Gintvile Valinciute,Yong Li,Xiang Fu,Lei Yang,Graham P. Marsh,G. Hughes,Burhan Karadogan,Dean Wheeler,Mark C. Norley,Freya Spain,Marjeta Urh,Martine F. Roussel,Björn Schwalb
comparative study with analogues containing alternative CRBN-directing warheads. Our study highlights the importance of considering warhead modifications when optimizing PROTACs for oral delivery.
PDF的下载单位、IP信息已删除
(2025-6-4)
GingerF
OsamaKareem
无极微光
Criminology34
chandangfo
乐空思
嘉心糖
XQQDD
YifanWang
Hayat
dashen
互助
369ninja
大布丁
千束
快点毕业
贪玩的秋柔
MchemG
周伯通
cc
皖公网安备34019202002308
