炎症
免疫系统
脂肪组织
癌症
免疫学
细胞因子
背景(考古学)
医学
白细胞介素6
白细胞介素
生物
癌症研究
内科学
古生物学
作者
Cameron Kowitt,Qiuyang Zhang
出处
期刊:Encyclopedia
[MDPI AG]
日期:2024-11-23
卷期号:4 (4): 1770-1789
标识
DOI:10.3390/encyclopedia4040117
摘要
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family. It is primarily associated with type 2 immune responses. It interacts with a receptor complex on immune cells in reaction to tissue damage or cellular injury. IL-33 is crucial in immune responses and is involved in various autoimmune and inflammatory diseases. Obesity is marked by chronic inflammation and is a known risk factor for several types of cancer. Recent studies have shown that IL-33 and its receptor complex are expressed in adipose (fat) tissue, suggesting they may play a role in obesity. While inflammation connects obesity and cancer, it is not yet clear whether IL-33 contributes to cancer associated with obesity. Depending on the cellular context, inflammatory environment, expression levels, and bioactivity, IL-33 can exhibit both protumorigenic and antitumorigenic effects. This review will explore the various functions of IL-33 in the inflammation linked to obesity and its relationship with cancer.
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