化学
区域选择性
环异构化
戒指(化学)
吡咯
结构异构体
环丙烷化
药物化学
组合化学
立体化学
有机化学
催化作用
作者
Dirgha Raj Joshi,Ikyon Kim
标识
DOI:10.1002/adsc.202200590
摘要
Abstract A modular approach to a wide range of 1‐cyano‐3‐(hetero)arylindolizines through aldol‐cyclopropanation‐oxidative cycloisomerization is described where DDQ was utilized for the regioselective synthesis of the pyrrole units from cyclopropyl pyridines for the first time. A key to success is regioselective oxidation of benzylic position by DDQ, which enabled us to access to one regioisomer out of two possible ones. Homo‐dimerization at the C2, C5, or C7 sites of indolizines in the presence of DDQ has been discovered for the first time as well. magnified image
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