医学
磁共振成像
脂肪营养不良
骨髓
放射科
病理
病毒载量
家庭医学
抗逆转录病毒疗法
人类免疫缺陷病毒(HIV)
作者
T F T de Oliveira,Marcelo Ricardo Canuto Natal,A A Teixeira,B B Machado
出处
期刊:DOAJ: Directory of Open Access Journals - DOAJ
日期:2022-11-10
卷期号:68 (4): 236-238
标识
DOI:10.4103/jpgm.jpgm_1031_21
摘要
Cystic bone lesions are the hallmark of skeletal abnormalities in patients with congenital generalized lipodystrophy (CGL). However, their pathophysiology is still unclear and theories about their origin remain largely speculative. This article reports on a patient with CGL and cystic bone lesions, some of them with unusual magnetic resonance imaging (MRI) findings that include elevated signal intensity on T1-weighted images and fluid-fluid levels, the latter evolving to a more "classic" cystic appearance on follow-up. Even though similar findings were first described almost 30 years ago, little attention was given to them back then; furthermore, other than the present report, no other study has performed sequential exams to follow their evolution in serial MRI. The authors conduct a review of the literature, hypothesizing that these remarkable findings may reflect an intermediate stage in the process of cystification of the abnormal bone marrow, incapable to perform adipose conversion, lending factual support to the modern theories about this issue.
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