Preparation of novel chiral stationary phases based on a chiral trianglsalen macrocycle by thiol-ene click chemistry for enantioseparation in high-performance liquid chromatography

Two novel chiral stationary phases with different spacers were prepared by bonding a chiral trianglsalen macrocycle to thiol-functionalized silica via a thiol-ene click reaction for HPLC enantioseparation, exhibiting excellent enantioselectivity.