This study identified the preferred features of HIV/STI prevention mobile health (mHealth) apps among rural sexual minority men (SMM) in the southern U.S. and examined preference differences by HIV risk factors. Participants (N = 406) completed an online cross-sectional survey. A series of multiple logistic regression models were used to examine differences. The top three preferred features included ordering at-home STI testing kits, ordering at-home HIV testing kits, and providing a list of local sexual health providers and professionals. HIV risk factor differences were found in participants who had engaged in condomless anal sex and who had been diagnosed with an STI being more likely to prefer the app to have the ability to synchronously or asynchronously talk to a sexual health professional, young adults being less likely to prefer various features, and racial/ethnic minority participants being more likely to prefer various features than non-Hispanic White participants.