清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress

细胞生物学 粘合连接 细胞外基质 串扰 形态发生 生物 细胞 电池极性 细胞生长 上皮-间质转换 过渡(遗传学) 钙粘蛋白 遗传学 基因 光学 物理
作者
Björn L.D.M. Brücher,Ijaz S. Jamall
出处
期刊:4 open [EDP Sciences]
卷期号:2: 14-14 被引量:10
标识
DOI:10.1051/fopen/2018996
摘要

The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with incessant inflammation. This persistent inflammation, when unresolved, induces fibrosis with consequent remodeling of the extracellular matrix (ECM) which leads to the formation of the precancerous niche (PCN), the tipping point in the transition of normal to cancerous cells. Thus, the sustained disruption of homeostasis when confronted with limited adaptation capabilities either of cells or of the surrounding matrix and faced with chronic stress in the tissue microenvironment results in an escape strategy which, if unsuccessful, causes cells, tissue, or the organism to become unable to recover over the long term. All conditions necessary for cell–cell transition such as deregulation of cell–cell complexes, decrease in the stability of adherens junctions, together with the apical-basal polarity, and the loss of the cytoskeletal architecture occurs as a cascade of events inducing inappropriate and diverse signaling pathways and crosstalk. In biology, the transition of one cell type to another and the transition from one cell function to another is incompletely understood mechanistically, but within the context of embryogenesis and morphogenesis is acknowledged as a physiologically routine event. The constant stress that can result in the development of the PCN leads to a chronic stress escape strategy (CSES) which, if unsuccessful, eventually triggers a normal cell- to-cancer cell- transition (NCCCT).

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
合适乐巧完成签到 ,获得积分10
4秒前
badgerwithfisher完成签到,获得积分10
6秒前
11秒前
tangtang完成签到 ,获得积分10
18秒前
科研小秦完成签到,获得积分10
19秒前
脑洞疼应助ahoshuo采纳,获得10
34秒前
温柔樱桃完成签到 ,获得积分10
38秒前
迅速的念芹完成签到 ,获得积分10
39秒前
小河流水完成签到 ,获得积分10
50秒前
51秒前
51秒前
PhD完成签到,获得积分10
53秒前
54秒前
泽2011完成签到 ,获得积分10
56秒前
1分钟前
ahoshuo发布了新的文献求助10
1分钟前
1分钟前
1分钟前
1分钟前
北枳完成签到,获得积分10
1分钟前
1分钟前
研友_Ljb0qL完成签到,获得积分10
1分钟前
2分钟前
www完成签到 ,获得积分10
2分钟前
2分钟前
小敏爱吃鱼完成签到,获得积分10
2分钟前
南风完成签到 ,获得积分10
2分钟前
2分钟前
Alvin完成签到 ,获得积分10
2分钟前
2分钟前
2分钟前
woleaisa完成签到,获得积分10
2分钟前
王丽莎完成签到 ,获得积分10
2分钟前
woleaisa发布了新的文献求助10
2分钟前
赘婿应助科研通管家采纳,获得10
2分钟前
3分钟前
Ryan完成签到 ,获得积分10
3分钟前
sang完成签到 ,获得积分10
3分钟前
widesky777完成签到 ,获得积分0
3分钟前
简爱完成签到 ,获得积分10
3分钟前
高分求助中
Adhesion Science: Principles & Practice 1234
Signals, Systems, and Signal Processing 610
Petrology and Plate Tectonics,2025 450
Circular Polar Constellations Providing Continuous Single or Multiple Coverage Above a Specified Latitude 400
Social democracy and urban politics Party responses to the diversifying left in European cities 400
Burger's Medicinal Chemistry and Drug Discovery 400
Probability and Stochastic Processes 333
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 物理 内科学 复合材料 催化作用 物理化学 光电子学 电极 细胞生物学 基因 无机化学
热门帖子
关注 科研通微信公众号,转发送积分 6735031
求助须知:如何正确求助?哪些是违规求助? 8467930
关于积分的说明 18068577
捐赠科研通 5998466
什么是DOI,文献DOI怎么找? 3001191
邀请新用户注册赠送积分活动 1977590
关于科研通互助平台的介绍 1938378