肢端肥大症
生长激素受体
旁分泌信号
自分泌信号
Pegvisomant公司
内分泌系统
受体
激素
生长激素
内分泌学
医学
疾病
体内
内科学
生物
癌症研究
生物信息学
药理学
生物技术
作者
Man Lu,Jack U. Flanagan,Ries J. Langley,Michael P. Hay,Jo K. Perry
标识
DOI:10.1038/s41392-019-0036-y
摘要
Abstract Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for normal postnatal growth and has pleiotropic effects across multiple physiological systems. GH is also expressed in extrapituitary tissues and has localized autocrine/paracrine effects at these sites. In adults, hypersecretion of GH causes acromegaly, and strategies that block the release of GH or that inhibit GH receptor (GHR) activation are the primary forms of medical therapy for this disease. Overproduction of GH has also been linked to cancer and the microvascular complications that are associated with diabetes. However, studies to investigate the therapeutic potential of GHR antagonism in these diseases have been limited, most likely due to difficulty in accessing therapeutic tools to study the pharmacology of the receptor in vivo. This review will discuss current and emerging strategies for antagonizing GH function and the potential disease indications.
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