Synthesis and in vivo anti-inflammatory activity ofa novel series of benzoxazole derivatives

Novel series of benzoxazole derivatives were prepar ed by the condensation of methyl-2-(2aminothiazol-5-ylamino) benzo[d]oxazole-5-carboxyla te with various aromatic aldehydes. The structures of the synthesized compounds were VI 1-VI 15 assigned on the basis of elemental analysis, IR, 1 H NMR and mass spectroscopy. These compounds were a lso screened for antiinflammatory activity. The recorded percentage of i nhibition showed a significant antiinflammatory activity when compared to the referenc e anti-inflammatory drug diclofenac sodium.