异核单量子相干光谱
二维核磁共振波谱
化学
体外
糖苷
消炎药
三萜类
立体化学
抑制性突触后电位
化学成分
生物化学
生物
色谱法
药理学
神经科学
作者
Xin Liu,Chang-Cheng Yin,Yue Cao,Jianhua Zhou,Tao Wu,Zhihong Cheng
标识
DOI:10.1080/14786419.2017.1320795
摘要
A new triterpenoid glycoside (1) and 15 known compounds (2–16) were isolated from the whole plants of Gueldenstaedtia verna. The new compound (1) was identified as complogenin 22-O-β-d-glucopyranoside by extensive spectroscopic techniques including 1D (1H and 13C) and 2D NMR experiments (HSQC, HMBC and NOESY), HR-DART-MS and chemical methods. Most of the isolates were evaluated for their inhibitory activities on LPS-induced NO production in RAW 264.7 cells. The inhibitory effects of the active compounds, sulphuretin (8) and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol (13), on the production of pro-inflammatory mediators (including IL-6, IL1β and PGE2) were further estimated in vitro by ELISA in RAW 264.7 macrophages.
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