生物
细胞生物学
细胞骨架
细胞融合
肌动蛋白
融合机制
合子
波姆裂殖酵母
裂殖酵母
脂质双层融合
细胞
胞质分裂
遗传学
细胞分裂
膜
酵母
胚胎发生
酿酒酵母
胚胎
标识
DOI:10.1016/j.semcdb.2016.07.025
摘要
Cell-cell fusion is a ubiquitous process that underlies fertilization and development of eukaryotes. This process requires fusogenic machineries to promote plasma membrane merging, and also relies on the organization of dedicated sub-cortical cytoskeletal assemblies. This review describes the role of actin structures, so called actin fusion foci, essential for the fusion of two distinct cell types: Drosophila myoblast cells, which fuse to form myotubes, and sexually differentiated cells of the fission yeast Schizosaccharomyces pombe, which fuse to form a zygote. I describe the respective composition and organization of the two structures, discuss their proposed role in promoting plasma membrane apposition, and consider the universality of similar structures for cell-cell fusion.
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