Bio-inspired natural platelet hydrogels for wound healing

Wound healing has invariably been a fundamental health concern, demanding manpower and materials and causing financial burdens. In this research, inspired by the hemostatic function of platelets, we proposed a novel bionic hydrogel by covalent amidation crosslinking natural platelet and alginate for wound healing. With the natural functional groups, the platelet-derived hydrogel exhibited outstanding biocompatibility and blood compatibility. By changing the addition ratio of platelets to alginates, the mechanical properties of the achieved hydrogel were variable to cater to different wound environments. Furthermore, silver nanoparticles could be loaded into the void space of the hydrogel which endowed the composites with superior anti-infective properties. We have demonstrated that the bio-inspired platelet hydrogel could promote hemostasis of acute tissue damage, prevent bacterial proliferation, and promote angiogenesis, collagen deposition, and granulation tissue formation in wound healing. These features signify the potential values of the bio-inspired platelet hydrogel in clinical applications.