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HomeCirculationVol. 149, No. 16Nanopore Detection of METTL3-Dependent m6A-Modified mRNA Reveals a New Mechanism Regulating Cardiomyocyte Mitochondrial Metabolism No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextNanopore Detection of METTL3-Dependent m6A-Modified mRNA Reveals a New Mechanism Regulating Cardiomyocyte Mitochondrial Metabolism Charles P. Rabolli, Isabel S. Naarmann-de Vries, Catherine A. Makarewich, Kedryn K. Baskin, Christoph Dieterich and Federica Accornero Charles P. RabolliCharles P. Rabolli https://orcid.org/0000-0002-4383-8706 Departments of Physiology and Cell Biology (C.P.R., K.K.B., F.A.), The Ohio State University, Columbus. Biomedical Engineering (C.P.R.), The Ohio State University, Columbus. Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus (C.P.R., K.K.B., F.A.). Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI (C.P.R., F.A.). , Isabel S. Naarmann-de VriesIsabel S. Naarmann-de Vries Section of Bioinformatics and Systems Cardiology, Klaus Tschira Institute for Integrative Computational Cardiology (I.S.N.-d.V., C.D.), University Hospital Heidelberg, Germany. Department of Internal Medicine III (Cardiology, Angiology, and Pneumology; I.S.N.-d.V., C.D.), University Hospital Heidelberg, Germany. German Centre for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany (I.S.N.-d.V., C.D.). , Catherine A. MakarewichCatherine A. Makarewich https://orcid.org/0000-0001-6907-4401 The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, OH (C.A.M.). Department of Pediatrics, University of Cincinnati College of Medicine, OH (C.A.M.). , Kedryn K. BaskinKedryn K. Baskin https://orcid.org/0000-0003-3187-9655 Departments of Physiology and Cell Biology (C.P.R., K.K.B., F.A.), The Ohio State University, Columbus. Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus (C.P.R., K.K.B., F.A.). , Christoph DieterichChristoph Dieterich Section of Bioinformatics and Systems Cardiology, Klaus Tschira Institute for Integrative Computational Cardiology (I.S.N.-d.V., C.D.), University Hospital Heidelberg, Germany. Department of Internal Medicine III (Cardiology, Angiology, and Pneumology; I.S.N.-d.V., C.D.), University Hospital Heidelberg, Germany. German Centre for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany (I.S.N.-d.V., C.D.). and Federica AccorneroFederica Accornero Correspondence to: Federica Accornero, PhD, Molecular Biology, Cell Biology, & Biochemistry, Brown University, Sidney Frank Hall, Box G-L 206C, 185 Meeting St, Providence, RI 02912. Email E-mail Address: [email protected] https://orcid.org/0000-0003-1209-7228 Departments of Physiology and Cell Biology (C.P.R., K.K.B., F.A.), The Ohio State University, Columbus. Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus (C.P.R., K.K.B., F.A.). Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI (C.P.R., F.A.). Originally published15 Apr 2024https://doi.org/10.1161/CIRCULATIONAHA.123.066473Circulation. 2024;149:1319–1322FootnotesFor Sources of Funding and Disclosures, see page 1322.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Federica Accornero, PhD, Molecular Biology, Cell Biology, & Biochemistry, Brown University, Sidney Frank Hall, Box G-L 206C, 185 Meeting St, Providence, RI 02912. Email federica_accornero@brown.eduREFERENCES1. Dorn LE, Lasman L, Chen J, Xu X, Hund TJ, Medvedovic M, Hanna JH, van Berlo JH, Accornero F. The N(6)-methyladenosine mRNA methylase METTL3 controls cardiac homeostasis and hypertrophy.Circulation. 2019; 139:533–545. doi: 10.1161/CIRCULATIONAHA.118.036146LinkGoogle Scholar2. Hinger SA, Wei J, Dorn LE, Whitson BA, Janssen PML, He C, Accornero F. Remodeling of the m(6)A landscape in the heart reveals few conserved post-transcriptional events underlying cardiomyocyte hypertrophy.J Mol Cell Cardiol. 2021; 151:46–55. doi: 10.1016/j.yjmcc.2020.11.002CrossrefMedlineGoogle Scholar3. Kmietczyk V, Riechert E, Kalinski L, Boileau E, Malovrh E, Malone B, Gorska A, Hofmann C, Varma E, Jurgensen L, et al. m(6)A-mRNA methylation regulates cardiac gene expression and cellular growth.Life Sci Alliance. 2019; 2:e201800233. doi: 10.26508/lsa.201800233CrossrefMedlineGoogle Scholar4. Mathiyalagan P, Adamiak M, Mayourian J, Sassi Y, Liang Y, Agarwal N, Jha D, Zhang S, Kohlbrenner E, Chepurko E, et al. FTO-dependent N(6)-methyladenosine regulates cardiac function during remodeling and repair.Circulation. 2019; 139:518–532. doi: 10.1161/CIRCULATIONAHA.118.033794LinkGoogle Scholar5. Piechotta M, Naarmann-de Vries IS, Wang Q, Altmuller J, Dieterich C. RNA modification mapping with JACUSA2.Genome Biol. 2022; 23:115. doi: 10.1186/s13059-022-02676-0CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. 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