240P Feasibility of detecting NSCLC-associated fusion genes in long-term preserved FFPE samples

mRNA testing in NSCLC patients enhances the detection of mutations like ALK, RET, ROS1, and MET exon14 skipping. Due to mRNA's vulnerability to degradation, strict testing standards are required. The current consensus is that samples stored for less than three years are suitable for detection and treatment guidance. However, the suitability of longer-stored samples for mRNA-based fusion testing remains uncertain. This study evaluates the efficacy of AmoyDx 11-gene PCR in detecting fusion genes in long-term preserved FFPE samples.