血小板
体内
炎症
血小板活化
体外
内皮
粘附
脂多糖
细胞生物学
化学
免疫学
生物物理学
医学
生物
生物化学
内科学
生物技术
有机化学
作者
Alison Banka,Maria Valentina Guevara,Emma R. Brannon,Nhien Nguyen,Shuang Song,Gillian Cady,David J. Pinsky,Kathryn E. Uhrich,Reheman Adili,Michael Holinstat,Omolola Eniola‐Adefeso
标识
DOI:10.1038/s41467-023-37990-z
摘要
The combination of inflammation and thrombosis is a hallmark of many cardiovascular diseases. Under such conditions, platelets are recruited to an area of inflammation by forming platelet-leukocyte aggregates via interaction of PSGL-1 on leukocytes and P-selectin on activated platelets, which can bind to the endothelium. While particulate drug carriers have been utilized to passively redirect leukocytes from areas of inflammation, the downstream impact of these carriers on platelet accumulation in thromboinflammatory conditions has yet to be studied. Here, we explore the ability of polymeric particles to divert platelets away from inflamed blood vessels both in vitro and in vivo. We find that untargeted and targeted micron-sized polymeric particles can successfully reduce platelet adhesion to an inflamed endothelial monolayer in vitro in blood flow systems and in vivo in a lipopolysaccharide-induced, systemic inflammation murine model. Our data represent initial work in developing cargo-free, anti-platelet therapeutics specifically for conditions of thromboinflammation.
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