内质网
内膜系统
膜接触部位
生物
细胞生物学
脂滴
神经退行性变
细胞器
囊泡转运蛋白
轴突
膜蛋白
轴浆运输
整体膜蛋白
小泡
膜
生物化学
高尔基体
医学
疾病
病理
作者
Andrés Guillén-Samander,Pietro De Camilli
出处
期刊:Cold Spring Harbor Perspectives in Biology
[Cold Spring Harbor Laboratory]
日期:2022-09-19
卷期号:15 (4): a041257-a041257
被引量:15
标识
DOI:10.1101/cshperspect.a041257
摘要
The Endoplasmic Reticulum (ER) is an endomembrane system that plays a multiplicity of roles in cell physiology and populates even the most distal cell compartments, including dendritic tips and axon terminals of neurons. Some of its functions are achieved by a cross talk with other intracellular membranous organelles and with the plasma membrane at membrane contacts sites (MCSs). As the ER synthesizes most membrane lipids, lipid exchanges mediated by lipid transfer proteins at MCSs are a particularly important aspect of this cross talk, which synergizes with the cross talk mediated by vesicular transport. Several mutations of genes that encode proteins localized at ER MCSs result in familial neurodegenerative diseases, emphasizing the importance of the normal lipid traffic within cells for a healthy brain. Here, we provide an overview of such diseases, with a specific focus on proteins that directly or indirectly impact lipid transport.
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