掷骰子
ALDH2
医学
小RNA
细胞生物学
线粒体生物发生
醛脱氢酶
药理学
线粒体
生物化学
生物
酶
RNA干扰
基因
核糖核酸
作者
Ligia Akemi Kiyuna,Darlan S. Candido,Luiz Roberto Grassmann Bechara,Itamar Couto Guedes de Jesus,Lisley Santos Ramalho,Bárbara Nunes Krum,Rudá Prestes e Albuquerque,Juliane C. Campos,Luiz H. M. Bozi,Vanessa O. Zambelli,Ariane Nunes‐Alves,Nicolás Campolo,Mauricio Mastrogiovanni,Silvina Bartesaghi,Alejandro Leyva,Rosario Durán,Rafael Radí,Guilherme M. Arantes,Edécio Cunha‐Neto,Marcelo A. Mori
标识
DOI：10.1093/eurheartj/ehad662
摘要
4-HNE inhibition of Dicer directly impairs miRNA biogenesis in heart failure. Strikingly, decreasing cardiac 4-HNE levels through pharmacological ALDH2 activation is sufficient to re-establish Dicer activity and miRNA biogenesis; thereby representing potential treatment for patients with heart failure.
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(2025-6-4)
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