化学
试剂
组合化学
肽
肽合成
功能群
基质(水族馆)
反应条件
有机化学
催化作用
生物化学
海洋学
地质学
聚合物
作者
Eti Chetankumar,Swetha Bharamawadeyar,C. Srinivasulu,Vommina V Sureshbabu
摘要
A simple, broadly applicable protocol for amidation and esterification reactions is described. Thereby, 4-acetamidophenyl triflimide (AITF), a crystalline stable reagent, is employed for the activation of carboxylic acids. The use of AITF as a coupling agent is demonstrated in the synthesis of peptides, amides and esters under mild conditions in good to excellent yields. Notably, peptide segment condensations were also accomplished. A diverse array of synthetic protocols showcasing a broad substrate scope and good functional group compatibility were accomplished. Herein, we systematically summarized the use of AITF in peptide synthesis strategies.
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