壳聚糖
神经导管
再生(生物学)
雪旺细胞
周围神经损伤
生物医学工程
周围神经
脚手架
外围设备
组织工程
化学
材料科学
解剖
医学
细胞生物学
内科学
生物
生物化学
作者
Zhiwen Jiang,Yijie Zhang,Yanting Wang,Shuo Wang,Jing Chang,Wanshun Liu,Baoqin Han
标识
DOI:10.1016/j.carbpol.2022.120327
摘要
In this study, a chitosan-based composite multichannel nerve conduit consisting of a warp-knitted chitosan scaffold and internally oriented N-succinyl-chitosan (NS-chitosan) fibers was applied to bridge a 10-mm nerve defect in rats. This study confirmed that an external pipeline with appropriate mechanical support was obtained by warp knitting techniques and that NS-chitosan fibers were not toxic to L-929 and PC-12 cells. These fibers degraded slowly for over 90 days and exerted sustained neuroprotective effects on peripheral nerves through their ability to drive cellular migration, promote survival, and block apoptosis of damaged Schwann cells through the Bcl-2/Bax/caspase-3 pathway. The multichannel chitosan/NS-chitosan conduit represented a histologically and functionally successful nerve reconstruction across a damaged 10-mm peripheral nerve model, showing regenerative efficacy equal to that of an autograft. The results demonstrated that the chitosan/NS-chitosan conduit with a warp-knitted tube construct and aligned inner fiber had good mechanical and bioactive properties for nerve repair.
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