自愈水凝胶
材料科学
再生医学
再生(生物学)
骨愈合
肿瘤微环境
生物医学工程
纳米技术
细胞生物学
免疫系统
免疫学
干细胞
医学
生物
解剖
高分子化学
作者
Nuo Li,Lijun Liu,Changbo Wei,Sicong Ren,Xinchen Liu,Xiaomeng Wang,Jiazhuo Song,Yuhuan Li,Zhuoran Wang,Shuwei Qiao,Xiangyu Yan,Shanchang Li,Huan Wang,Yanmin Zhou,Daowei Li
标识
DOI:10.1021/acsami.2c16774
摘要
Autologous blood-derived protein hydrogels have shown great promise in the field of personalized regenerative medicine. However, the inhospitable regenerative microenvironments, especially the unfavorable immune microenvironment, are closely associated with their limited tissue-healing outcomes. Herein, novel immunomodulatory blood-derived hybrid hydrogels (PnP-iPRF) are rationally designed and constructed for enhanced bone regeneration via multichannel regulation of the osteogenic microenvironment. Such double-network hybrid hydrogels are composed of clinically approved injectable platelet-rich fibrin (i-PRF) and polycaprolactone/hydroxyapatite composite nanofibers by using enriched polydopamine (PDA) as the anchor. The polycaprolactone component in PnP-iPRF provides a reinforced structure to stimulate osteoblast differentiation in a proper biomechanical microenvironment. Most importantly, the versatile PDA component in PnP-iPRF can not only offer high adhesion capacity to the growth factors of i-PRF and create a suitable biochemical microenvironment for sustained osteogenesis but also reprogram the osteoimmune microenvironment via the induction of M2 macrophage polarization to promote bone healing. The present study will provide a new paradigm to realize enhanced osteogenic efficacy by multichannel microenvironment regulations and give new insights into engineering high-efficacy i-PRF hydrogels for regenerative medicine.
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