刺
先天免疫系统
生物
信号转导
细胞生物学
神经退行性变
信号转导衔接蛋白
免疫学
免疫系统
医学
疾病
工程类
航空航天工程
病理
作者
Run Fang,Qifei Jiang,Xiaoyu Yu,Zhen Zhao,Zhengfan Jiang
出处
期刊:Advances in Immunology
日期:2022-01-01
卷期号:: 55-102
被引量:7
标识
DOI:10.1016/bs.ai.2022.09.003
摘要
The cGAS-STING pathway is responsible for cytoplasmic double-stranded DNA (dsDNA) -triggered innate immunity and involved in the pathology of various diseases including infection, autoimmune diseases, neurodegeneration and cancer. Understanding the activation and regulatory mechanisms of this pathway is critical to develop therapeutic strategies toward these diseases. Here, we review the signal transduction, cellular functions and regulations of cGAS and STING, particularly highlighting the latest understandings on the activation of cGAS by dsDNA and/or Manganese (Mn2+), STING trafficking, sulfated glycosaminoglycans (sGAGs)-induced STING polymerization and activation, and also regulation of the cGAS-STING pathway by different biocondensates formed via phase separation of proteins from host cells and viruses.
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