透皮
渗透
离子导入
扩散
化学
药物输送
电解质
毒品携带者
自愈水凝胶
色谱法
多孔性
材料科学
溶解试验
卡拉胶
透皮贴片
生物医学工程
溶解
纳米技术
药理学
高分子化学
有机化学
电极
物理化学
膜
医学
生物制药分类系统
放射科
物理
热力学
生物化学
作者
Tidayu Saramas,Phimchanok Sakunpongpitiporn,Kornkanok Rotjanasuworapong,Rawita Morarad,Sumonman Niamlang,Anuvat Sirivat
标识
DOI:10.1016/j.ijbiomac.2022.11.098
摘要
Transdermal drug delivery system (TDDS) is the system for transmitting a drug through the skin into the blood circulation. In this work, κ-Carrageenan (κC) was used as the drug matrix material. The porous κC matrices were fabricated by dissolving the κC in deionized water to obtain hydrogels and then using the freeze-dryer to obtain cryogels. The porous (κC) matrices showed interconnected pore sizes varying between 6.05 to 25.8 nm. In the drug release experiments, the drug diffusion coefficient increased and the drug release duration was reduced with decreasing κC concentration due to the larger κC pore sizes. The diffusion coefficient increased with a shorter release time under the applied electric strength of +1.0 V due to the electro-repulsive force between the Metformin and the anode. For the drug release-permeation of the κC 0.8 % v/v cryogel through the pig skin under applied positive electrical potentials, the amounts of drug release-permeation and diffusion coefficients were enhanced with shorter durations relative to without electrical potential. The κC 0.8 % v/v matrix at the applied electric strength of +6.0 V has been shown here to be potential to be used as the Metformin transdermal controlled delivery patch for abdominal obesity and diabetes.
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