生物
免疫系统
细胞生物学
浆细胞样树突状细胞
滤泡树突状细胞
抗原呈递
CD40
抗原提呈细胞
树突状细胞
KLF4公司
免疫学
转录因子
T细胞
细胞毒性T细胞
遗传学
基因
SOX2
体外
作者
Patrick Rodrigues,Athanasios Kouklas,Grozdan Cvijetic,Nicolas Bouladoux,Mladen Mitrovic,Jigar V. Desai,Djalma S. Lima-Jùnior,Michail S. Lionakis,Yasmine Belkaid,Robert Ivánek,Roxane Tussiwand
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2023-02-24
卷期号:8 (80)
被引量:9
标识
DOI:10.1126/sciimmunol.add4132
摘要
Plasmacytoid dendritic cells (pDCs) have been shown to play an important role during immune responses, ranging from initial viral control through the production of type I interferons to antigen presentation. However, recent studies uncovered unexpected heterogeneity among pDCs. We identified a previously uncharacterized immune subset, referred to as pDC-like cells, that not only resembles pDCs but also shares conventional DC (cDC) features. We show that this subset is a circulating precursor distinct from common DC progenitors, with prominent cDC2 potential. Our findings from human CD2-iCre and CD300c-iCre lineage tracing mouse models suggest that a substantial fraction of cDC2s originates from pDC-like cells, which can therefore be referred to as pre-DC2. This precursor subset responds to homeostatic cytokines, such as macrophage colony stimulating factor, by expanding and differentiating into cDC2 that efficiently prime T helper 17 (T H 17) cells. Development of pre-DC2 into CX3CR1 + ESAM − cDC2b but not CX3CR1 − ESAM + cDC2a requires the transcription factor KLF4. Last, we show that, under homeostatic conditions, this developmental pathway regulates the immune threshold at barrier sites by controlling the pool of T H 17 cells within skin-draining lymph nodes.
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