Dichotomous STAT5 and STAT6 Activation in T Cells Reflects Cytokine Shifts Between Blood and Skin in Atopic Dermatitis

We assessed STAT activation in T cells in blood and skin of AD patients versus HC. pSTAT5+ T cells were increased in AD blood, correlated with disease activity, and were induced by common γc cytokines. Skin T cells exhibited a STAT6 signature, whereas only a subset was positive for STAT5. AD, atopic dermatitis; HC, healthy controls; STAT: Signal Transducers and Activators of Transcription. The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.