医学
牙周炎
内科学
C反应蛋白
胃肠病学
随机对照试验
前瞻性队列研究
根管
牙科
炎症
作者
Mauricio Garrido,María José Bordagaray,Catalina Schweitzer,Joaquín Lucero‐Mora,María Isabel Pávez Reyes,Elizabeth Pellegrini,Patricia Hernández‐Ríos,Alejandra Fernández,Marcela Hernández
摘要
Abstract Aim To determine the systemic inflammatory burden, including hsCRP and its monomeric forms, in patients with apical lesions of endodontic origin treated with root canal treatment (RCT). Methodology Prospective pre‐/post‐study. Apical periodontitis (AP) individuals aged 16–40 were included ( N = 29). Individuals received RCT and were followed at 1 and 6 months. Fasting blood samples were obtained. Apical lesions of endodontic origin (ALEO) diameter (mm), and periapical index (PAI), were recorded. The serum concentrations of total hsCRP were determined by turbidimetry. Tumour necrosis factor (TNF)‐α, interleukin (IL)‐6, IL‐10, IL‐1β, and soluble (s) E‐selectin were assessed by Multiplex assay. Additionally, mCRP forms were determined in the serum of AP patients with a baseline moderate to high cardiovascular risk based on hsCRP stratification (hsCRP ≥1 mg/L) by immunowestern blot ( n = 15). Also, CRP isoforms were explored in ALEOs from AP individuals ( n = 4). Data were analysed with StataV16. Results Periapical index and ALEO sizes were reduced at both follow‐up visits after RCT ( p < .05). Serum levels of TNF‐α, IL‐6, IL‐10, IL‐1β, and sE‐selectin did not show significant differences. CRP was borderline reduced at 1 month ( p = .04); however, in AP individuals at cardiovascular risk (hsCRP ≥ 1 mg/L), hsCRP and its monomeric isoform significantly decreased at 1 and 6 months ( p < .05). Conclusions High‐sensitivity CRP and mCRP are reduced after RCT in AP individuals at cardiovascular risk.
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