乙二醇
PEG比率
药物输送
药品
体内
体内分布
化学
纳米技术
聚乙二醇化
靶向给药
聚合物
化学工程
材料科学
药理学
聚乙二醇
有机化学
医学
体外
生物化学
生物技术
财务
工程类
经济
生物
作者
Shiyao Li,Yun-Xiang Ma,Jiwei Cui,Frank Caruso,Yi Ju
摘要
Poly(ethylene glycol) (PEG) is considered to be the "gold standard" among the stealth polymers employed for drug delivery. Using PEG to modify or engineer particles has thus gained increasing interest because of the ability to prolong blood circulation time and reduce nonspecific biodistribution of particles in vivo, owing to the low fouling and stealth properties of PEG. In addition, endowing PEG-based particles with targeting and drug-loading properties is essential to achieve enhanced drug accumulation at target sites in vivo. In this feature article, we focus on recent work on the synthesis of PEG particles, in which PEG is the main component in the particles. We highlight different synthesis methods used to generate PEG particles, the influence of the physiochemical properties of PEG particles on their stealth and targeting properties, and the application of PEG particles in targeted drug delivery.
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