激酶
丝氨酸
苏氨酸
细胞生物学
磷酸化
生物
AKT3
功能(生物学)
B细胞
细胞生长
免疫学
抗体
生物化学
作者
Zhennan Han,Kamel Benlagha,Pamela Lee,Chan-Sik Park,Alexander Filatov,Maria G. Byazrova,H I Miller,Lu Yang,Chaohong Liu
标识
DOI:10.3389/fimmu.2024.1459527
摘要
The serine/threonine-specific protein kinases (STKs) are important for cell survival, proliferation, differentiation, and apoptosis. In B cells, these kinases play indispensable roles in regulating important cellular functions. Multiple studies on human and other animal cells have shown that multiple STKs are involved in different stages of B cell development and antibody production. However, how STKs affect B cell development and function is still not completely understood. Considering that B cells are clinically important in immunity and diseases, our understanding of STKs’ roles in B cells is in great need of investigation with current technologies. Investigating serine/threonine kinases will not only deepen our insight into B cell-related disorders but also facilitate the identification of more effective drug targets for conditions like lymphoma and systemic lupus erythematosus.
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