环状RNA
小RNA
癌症研究
转移
淋巴结转移
微阵列
癌症
活检
基底细胞
医学
淋巴结
核糖核酸
病理
生物
基因表达
基因
内科学
生物化学
作者
Toshiaki Ando,Atsushi Kasamatsu,Kohei Kawasaki,Kazuya Hiroshima,Reo Fukushima,Manabu Iyoda,Daisuke Nakashima,Yosuke Endo‐Sakamoto,Katsuhiro Uzawa
出处
期刊:Cancers
[MDPI AG]
日期:2021-11-15
卷期号:13 (22): 5708-5708
被引量:4
标识
DOI:10.3390/cancers13225708
摘要
Circular RNAs (circRNAs), which form as covalently closed loop structures, have several biological functions such as regulation of cellular behavior by adsorbing microRNAs. However, there is limited information of circRNAs in oral squamous cell carcinoma (OSCC). Here, we aimed to elucidate the roles of aberrantly expressed circRNAs in OSCC. CircRNA microarray showed that circRNA-102450 was down-regulated in OSCC cells. Clinical validation of circRNA-102450 was performed using highly sensitive droplet digital PCR in preoperative liquid biopsy samples from 30 OSCC patients. Interestingly, none of 16 studied patients with high circRNA-102450 had regional lymph node metastasis (RLNM), whereas 4 of 14 studied patients (28.5%) with low expression had pathologically proven RLNM. Overexpressed circRNA-102450 significantly inhibited the tumor metastatic properties of cell proliferation, migration, and invasion. Furthermore, circRNA-102450 directly bound to, and consequently down-regulated, miR-1178 in OSCC cells. Taken together, circRNA-102450 has a tumor suppressive effect via the circRNA-102450/miR-1178 axis and may be a novel potential marker of RLNM in OSCC patients.
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