NIR‐Triggered Multi‐Mode Antitumor Therapy Based on Bi2Se3/Au Heterostructure with Enhanced Efficacy

Abstract Of all the reaction oxygen species (ROS) therapeutic strategies, NIR light‐induced photocatalytic therapy (PCT) based on semiconductor nanomaterials has attracted increasing attention. However, the photocatalysts suffer from rapid recombination of electron‐hole pairs due to the narrow band gaps, which are greatly restricted in PCT application. Herein, Bi 2 Se 3 /Au heterostructured photocatalysts are fabricated to solve the problems by introducing Au nanoparticles (NPs) in situ on the surface of the hollow mesoporous structured Bi 2 Se 3 . Owing to the lower work function of Au NPs, the photo‐induced electrons are easier to transfer and assemble on their surfaces, resulting in the increased separation of the electron‐hole pairs with efficient ROS generation. Besides, Bi 2 Se 3 /Au heterostructures also enhance the photothermal efficiency due to the effective orbital overlaps with accelerated electron migrations according to density functional theory calculations. Moreover, the PLGA‐PEG and the doxorubicin (DOX) are introduced for photothermal‐triggered drug release in the system. The Bi 2 Se 3 /Au heterostructures also displays excellent infrared thermal (IRT) and computed tomography (CT) dual‐modal imaging property for promising cancer diagnosis. Collectively, Bi 2 Se 3 /Au@PLGA‐PEG‐DOX exhibits prominent tumor inhibition effect based on synchronous PTT, PCT and chemotherapy triggered by NIR light for efficient antitumor treatment.