奥美拉唑
脂肪酸合酶
医学
化疗
临床终点
内科学
紫杉烷
胃肠病学
肿瘤科
癌症
乳腺癌
临床试验
脂质代谢
作者
Sagar Sardesai,Alexandra Thomas,Christopher Gallagher,Filipa Lynce,Yvonne Ottaviano,Tarah J. Ballinger,Bryan P. Schneider,Anna Maria Storniolo,Amber Bauchle,Sandra K. Althouse,Susan M. Perkins,Andrea R. Masters,Robert E. Stratford,Zizheng Dong,Jingyuan Liu,Jian‐Ting Zhang,Kathy D. Miller
标识
DOI：10.1158/1078-0432.ccr-21-0493
摘要
FASN is commonly expressed in early TNBC. Omeprazole can be safely administered in doses that inhibit FASN. The addition of omeprazole to neoadjuvant AC-T yields a promising pCR rate that needs further confirmation in randomized studies.
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