前列腺癌
生物
生物标志物
跨膜蛋白
免疫疗法
计算生物学
癌症
功能(生物学)
磷脂酶
癌症免疫疗法
癌症研究
生物信息学
遗传学
受体
磷脂
磷脂酰丝氨酸
膜
作者
Jialong Guo,Dan Wang,Yuan Dong,Xiang Gao,Haibin Tong,Wei Liu,Lei Zhang,Meiyan Sun
出处
期刊:Tissue & Cell
[Elsevier]
日期:2021-10-01
卷期号:72: 101546-101546
被引量:7
标识
DOI:10.1016/j.tice.2021.101546
摘要
Anoctamin 7 (ANO7) is a member of the transmembrane protein TMEM16 family. It has a conservative topology similar to other members in this family, such as the typical eight-transmembrane domain, but it also has unique features. Although the ion channel role of ANO7 has been well accepted, evolutionary analyses and relevant studies suggest that ANO7 may be a multi-facet protein in function. Studies have shown that ANO7 may also function as a scramblase. ANO7 is highly expressed in prostate cancer as well as normal prostate tissues. A considerable amount of evidence has confirmed that ANO7 is associated with human physiology and pathology, particularly with the development of prostate cancer, which makes ANO7 a good candidate as a diagnostic and prognostic biomarker. In addition, ANO7 may be a potential target for prostate cancer immunotherapy. Antibody-based or T cell-mediated immunotherapies against prostate cancer by targeting ANO7 have been highly anticipated. ANO7 may also correlate with several other types of cancers or diseases, where further studies are warranted.
科研通智能强力驱动
Strongly Powered by AbleSci AI