Non-spherical micro- and nanoparticles for drug delivery: Progress over 15 years

Shape of particulate drug carries has been identified as a key parameter in determining their biological outcome. In this review, we analyze the field of particle shape as it shifts from fundamental investigations to contemporary applications for disease treatment, while highlighting outstanding remaining questions. We summarize fabrication and characterization methods and discuss in depth how particle shape influences biological interactions with cells, transport in the vasculature, targeting in the body, and modulation of the immune response. As the field moves from discoveries to applications, further attention needs to be paid to factors such as characterization and quality control, selection of model organisms, and disease models. Taken together, these aspects will provide a conceptual foundation for designing future non-spherical drug carriers to overcome biological barriers and improve therapeutic efficacy.