化学
硫酯
质子化
电化学
共轭体系
催化作用
吡啶
金属
光化学
串联
组合化学
有机化学
材料科学
电极
物理化学
复合材料
离子
酶
聚合物
作者
Hehuan Xu,Jiayu Liu,Feiyun Nie,Xiaowei Zhao,Zhiyong Jiang
标识
DOI:10.1021/acs.joc.1c01526
摘要
An electrochemical hydropyridylation of thioester-activated alkenes with 4-cyanopyridines has been developed. The reactions experience a tandem electroreduction of both substrates on the cathode surface, protonation, and radical cross-coupling process, resulting in a variety of valuable pyridine variants, which contain a tertiary and even a quaternary carbon at the α-position of pyridines, in high yields. The employment of thioesters to the conjugated alkenes enables no requirement of catalyst and high temperature, representing a highly sustainable synthetic method.
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