内大麻素系统
神经科学
突触后电位
突触可塑性
突触
神经传递
大麻素受体
变质塑性
生物
受体
生物化学
兴奋剂
作者
Bryony L. Winters,Christopher W. Vaughan
标识
DOI:10.1016/j.neuropharm.2021.108736
摘要
The endogenous cannabinoid transmitter system regulates synaptic transmission throughout the nervous system. Unlike conventional transmitters, specific stimuli induce synthesis of endocannabinoids (eCBs) in the postsynaptic neuron, and these travel backwards to modulate presynaptic inputs. In doing so, eCBs can induce short-term changes in synaptic strength and longer-term plasticity. While this eCB regulation is near ubiquitous, it displays major regional and synapse specific variations with different synapse specific forms of short-versus long-term plasticity throughout the brain. These differences are due to the plethora of pre- and postsynaptic mechanisms which have been implicated in eCB signalling, the intricacies of which are only just being realised. In this review, we shall describe the current understanding and highlight new advances in this area, with a focus on the retrograde action of eCBs at CB1 receptors (CB1Rs). This article is part of the special Issue on 'Cannabinoids'.
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