姜黄素
阿霉素
药理学
多重耐药
体内
细胞凋亡
药物输送
癌细胞
癌症研究
医学
化学
癌症
材料科学
化疗
纳米技术
生物
生物化学
内科学
抗生素
生物技术
作者
Fangyuan Guo,Nan Ye,Yunlong Jiao,Weiyong Hong,Kang Zhou,Xugang Ji,Yuan Huixing,Haiying Wang,Aiqin Li,Guoping Wang,Gensheng Yang
出处
期刊:Drug Delivery
[Informa]
日期:2021-01-01
卷期号:28 (1): 1709-1721
被引量:15
标识
DOI:10.1080/10717544.2021.1960926
摘要
Chemotherapeutic treatments are indispensable in the treatment of breast cancer. However, the emergence of multidrug-resistance, strong cell toxicity, and poor targeting selection has inhibited their clinical application. In this study, two synergistic drugs, doxorubicin (DOX) and curcumin (CUR), were co-administered to overcome multidrug resistance (MDR). Based on the characteristics of the tumor microenvironment, we developed folic acid-modified nanoparticles ((DOX + CUR)-FA-NPs) based on a star-shaped polyester (FA-TRI-CL) to enhance the tumor targeting selectivity and drug loading (DL) capacity. The (DOX + CUR)-FA-NPs displayed a characteristic spheroid morphology with an ideal diameter (186.52 nm), polydispersity index (0.024), zeta potential (-18.87 mV), and good entrapment efficiency (97.64%/78.13%, DOX/CUR) and DL (20.27%/11.29%, DOX/CUR) values. In vitro pharmacokinetic and pharmacodynamic experiments demonstrated that the (DOX + CUR)-FA-NPs were gradually released, and they displayed the highest cell apoptosis and cellular uptake in MCF-7/ADR cells. Additionally, in vivo results illustrated that (DOX + CUR)-FA-NPs not only displayed significant tumor targeting and anticancer efficacy, but also induced less pathological damage to the normal tissue. In summary, co-administered DOX and CUR appeared to reverse MDR, and this targeted combinational nanoscale delivery system could thus be a promising carrier for tumor therapies in the future.
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