High Enantioselective Organocatalytic Asymmetric Direct Aldol Reactions of Aldehydes with Long-Chain Aliphatic Ketones

Asymmetric organocatalysis have been developed explosively, since the pioneering work on\nproline-catalyzed asymmetric direct Aldol reaction reported by List, Barbas and coworkers[1].\nNumerous organocatalysts have been designed and the stereochemistry of the Aldol reactions has been\nsignificantly improved. However, organocatalytic direct aldol reactions of aldehydes with long-chain\nacyclic aliphatic ketones have been less investigated[2][3]. Herein, we report diamine catalytic aldol\nreaction of acyclic aliphatic ketones with aromatic aldehydes, providing high enantioselectivities. In\nneat condition, these aldol reactions afforded Aldol products with 80–96% ee.