离子通道
压电1
鉴定(生物学)
机械转化
生物物理学
纳米技术
化学
生物
神经科学
细胞生物学
计算生物学
材料科学
生物化学
受体
机械敏感通道
植物
作者
Boris Martinac,Kate Poole
标识
DOI:10.1016/j.biocel.2018.02.011
摘要
The ability of cells to sense and respond to their physical environment is fundamental to a broad spectrum of biological processes. Cells express an array of force sensors that can transduce mechanical inputs into biochemical signals, including the mechanically activated ion channels PIEZO1, PIEZO2 and TRPV4. The identification and characterisation of mechanically activated ion channels has proven challenging, as has identifying their mode of activation and regulation in vivo. However, the diverse channelopathies associated with the known channels highlights their physiological importance.
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