二维核磁共振波谱
立体化学
羧酸酯酶
化学
三萜类
传统医学
生物
植物
生物化学
酶
医学
作者
Yali Wang,Jing Zhao,Jiahao Liang,Xiangge Tian,Xiaokui Huo,Lei Feng,Jing Ning,Chao Wang,Baojing Zhang,Gang Chen,Ning Li,Cheng‐Peng Sun
标识
DOI:10.1080/14786419.2017.1408106
摘要
A new protostane-type triterpenoid, 5β,29-dihydroxy alisol A (1) was isolated from Alisma plantago-aquatica subsp. orientale (Sam.) Sam. as well as 12-deoxyphorbol-13α-pentadecanoate (2). We first report the presence of compound 2 in the genus Alisma. Their structures were established on the basis of 1D and 2D NMR, and HRESIMS spectroscopic analyses. All the isolated compounds were assayed for their inhibitory effects against human carboxylesterase 2 (HCE-2). Compounds 1 and 2 displayed inhibitory activities against HCE-2 with IC50 values of 29.2 and 4.6 μM, respectively. The interaction mechanisms of HCE-2 with compounds 1 and 2 were investigated by molecular docking, respectively.
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