表皮生长因子受体
对接(动物)
细胞毒性
体外
化学
表皮生长因子受体抑制剂
细胞培养
计算生物学
药理学
立体化学
受体
生物
生物化学
医学
遗传学
护理部
作者
Guo‐Wu Rao,Geng-Jie Xu,Jian Wang,Xuliang Jiang,Haibo Li
出处
期刊:ChemMedChem
[Wiley]
日期:2013-05-02
卷期号:8 (6): 928-933
被引量:13
标识
DOI:10.1002/cmdc.201300120
摘要
Strike a pose! A series of 4-anilinoquinazolines were designed, synthesized and evaluated in vitro against lung and breast cancer cell lines. Several compounds were found to be endowed with cytotoxicity in the low micromolar range. Molecular docking suggests that these compounds bind to EGFR in a similar manner to known EGFR inhibitors.
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