纤维化
纤维蛋白
胆管
整合素
病理
化学
激活剂(遗传学)
医学
癌症研究
细胞生物学
内科学
生物
免疫学
受体
作者
Nikita Joshi,Anna K. Kopec,Jessica L. Ray,Holly Cline-Fedewa,Atta Nawabi,Timothy M. Schmitt,Rance Nault,Timothy R. Zacharewski,Cheryl E. Rockwell,Matthew J. Flick,James P. Luyendyk
出处
期刊:Blood
[American Society of Hematology]
日期:2016-06-02
卷期号:127 (22): 2751-2762
被引量:31
标识
DOI:10.1182/blood-2015-09-670703
摘要
Key Points Fibrin engagement of leukocyte integrin-αMβ2 restricts bile duct hyperplasia and inhibits periductal fibrosis. Periductal fibrosis following bile duct injury is inhibited by leukadherin-1, an allosteric activator of integrin-αMβ2 fibrin binding.
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