对映选择合成
催化作用
化学
路易斯酸
氮原子
有机化学
组合化学
群(周期表)
标识
DOI:10.1002/anie.200462314
摘要
The direct introduction of either a nitrogen or oxygen atom adjacent to a carbonyl group in a catalytic, enantioselective manner using both chiral Lewis acid and Lewis base catalysis has been described recently. The enantiomerically enriched products of these reactions, such as alpha-amino acids, represent fundamental building blocks for the construction of complex natural products and other important bioactive molecules. This Minireview provides a synopsis of this ever-growing field and highlights some of the challenges that still remain.
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