Total Synthesis of (−)‐Lundurine A and Determination of its Absolute Configuration

Abstract A 15‐step total synthesis of (−)‐lundurine A ( 1 ) from easily accessible ( S )‐pyrrolidinone 18 is reported. A Simmons‐Smith reaction allows the efficient, simultaneous assembly of the cyclopropyl C ring, the six‐membered D ring, the seven‐membered E ring, and the quaternary carbon stereocenters at C2 and C7. The absolute configuration of natural (−)‐lundurine A was deduced to be 2 R ,7 R ,20 R based on the stepwise construction of the stereocenters during the total synthesis.