亚颗粒带
神经发生
室下区
神经保护
祖细胞
神经干细胞
细胞生物学
神经科学
生物
干细胞
作者
Xinzhou Zhu,Jeff Yan,Catherine Brégère,Andrea Zelmer,Tessa Goerne,Josef P. Kapfhammer,Raphael Guzman,Sven Wellmann
标识
DOI:10.1038/s41467-019-11870-x
摘要
Abstract Hypoxic ischemia (HI) is an acute brain threat across all age groups. Therapeutic hypothermia ameliorates resulting injury in neonates but its side effects prevent routine use in adults. Hypothermia up-regulates a small protein subset that includes RNA-binding motif protein 3 (RBM3), which is neuroprotective under stressful conditions. Here we show how RBM3 stimulates neuronal differentiation and inhibits HI-induced apoptosis in the two areas of persistent adult neurogenesis, the subventricular zone (SVZ) and the subgranular zone (SGZ), while promoting neural stem/progenitor cell (NSPC) proliferation after HI injury only in the SGZ. RBM3 interacts with IGF2 mRNA binding protein 2 (IMP2), elevates its expression and thereby stimulates IGF2 release in SGZ but not SVZ-NSPCs. In summary, we describe niche-dependent regulation of neurogenesis after adult HI injury via the novel RBM3-IMP2-IGF2 signaling pathway.
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