干细胞
造血
脐带血
移植
体细胞
重编程
人口
细胞生物学
生物
骨髓
医学
祖细胞
免疫学
细胞
遗传学
内科学
基因
环境卫生
作者
Chinyere Okeke,Ufele Silas,Chinedu Okeke,Chiedozie Chikwendu
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2021-02-12
卷期号:16 (2): 199-208
标识
DOI:10.2174/1574888x15999200729162021
摘要
Advances in single-cell technology and genetic mouse models have resulted in the identification of new types of hemopoietic stem cells (HSC), resulting in baffling observations, suggesting a reconsideration of the long-held notion that all hematopoietic cells in the adult are derived from HSCs. The existence of long-lived HSC-independent hematopoiesis has led to the conclusion that despite the single hierarchical differentiation route that generates functional blood types, other differentiation routes exist in-vivo. Heterogeneity in the HSC population and the evolving knowledge around HSC has translated to it's improved application as a therapeutic tool for various blood disorders. The reprogramming of non-hematopoietic somatic and mature blood cells to pluripotency with their subsequent differentiation into hematopoietic stem cells/progenitor cells and the introduction of new generation sequencing holds the potential for the resolution of ambiguities involved in HSC bone marrow transplantation. There is a change in the paradigm for HSC transplantation donor selection. Donor choice favors haploidentical HCT than cord blood. This review provides a general overview of the current events around hemopoietic stem cells, with emphasis on the rising trend of HSC transplantation, especially haploidentical stem cell transplantation.
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